课题组介绍
  • 党永军课题组
  • 刘俊彦课题组
  • 郭祖奉课题组
  • 聂神有课题组
  • 潘建波课题组
  • 袁海心课题组
  • 谌錾课题组
  • 党永军课题组

                 3E866

    党永军,重庆市侨联委员,国家级人才计划特聘教授,重庆医科大学特聘教授、药学院院长、新靶标与化学干预教育部医药基础研究创新中心主任,博士生导师。重庆英才·创新创业领军人才,巴渝学者计划讲座教授,重庆市教委高水平科研创新平台培育工程研究中心负责人,重庆市高校创新研究群体负责人,上海市人才发展基金获得者。复旦大学遗传所博士,美国约翰霍普金斯大学医学院博士后。中国药理学会海洋药物药理专业委员会副主任委员,全国卫生产业企业管理协会医学遗传专委会常务委员,上海药理学会常务理事,中国药学会第一届智能药物专业委员会委员,国家自然基金委二审专家。

    主要从事与疾病相关新靶标和小分子化合物的发现、确证以及转化医学研究。系统地建立了与疾病相关的分子靶标鉴定和小分子筛选体系,取得了系列原创性成果。近五年在重大疾病新靶标发现领域,以通讯作者身份在Signal Transduct Target TherBloodJ Clin InvestigNucleic Acids ResNat CommunAngew Chem Int EdAdv Sci等知名期刊发表论文18篇,其中影响因子大于10分的论文8篇。文章他引超6,500次,H指数36。主持国家自然科学基金重点项目1项,面上项目3项,参与国家重点研发计划“深海关键技术与装备”重点专项子课题1项。申请专利31项,实现项目转化7项,转化总金额3.28亿人民币。担任BloodCell Chem BiolBioorg Med Chem LettExp Cell ResACS Synth Biol等知名杂志审稿人。

    主要研究方向:1)天然产物和药物的分子靶点鉴定和作用机制研究;2)基于小分子探针的基础生物学理论研究;3)建立适于高通量筛选的细胞和动物模型用于新药的筛选和研发。


    代表性论文:

    1. R Wang#, L Xiao#, J Pan#, G Bao#, Y Zhu, D Zhu, J Wang, C Pei, Q Ma, X Fu, Z Wang, M Zhu, G Wang, L Gong, Q Tong, M Jiang, J Hu, M He, Y Wang, T Li, C Liang, W Li, C Xia, Z Li, DK Ma, M Tan, JY Liu, W Jiang*, C Luo*, B Yu*, Y Dang*. Natural product P57 induces hypothermia through targeting pyridoxal kinase. Nat Commun. 2023, 14(5984): 1-15.

    2. RN Wang#, Q Yu#, XB Wang, D Zhu, GL Li, ZX Li, W Jiang*, W Li*, YJ Dang*. Bis(benzonitrile) dichloroplatinum (II) interrupts PD-1/PD-L1 interaction by binding to PD-1. Acta Pharmacol Sin. 2023, 44: 2103-2112.

    3. X Wang#, J Huang#, F Liu#, Q Yu, R Wang, J Wang, Z Zhu, J Yu, J Hou, JS Shim, W Jiang*, Z Li*, Y Zhang*, Y Dang*. Aurora A kinase inhibition elevates PD-L1 expression and compromises its anti-tumor efficacy. J Clin Investig. 2023, 133(9): e161929.

    4. Q Li#, J Fan#, Y Chen, Y Liu, H Liu, W Jiang*, D Li*, Y Dang*. Marine-derived natural product HDYL-GQQ-495 targets P62 to inhibit autophagy. Mar Drugs. 2023, 21 (2): 68.

    5. Z Wang#, Y Li#, W Zhao#, S Jiang#, Y Huang, J Hou, X Zhang, Z Zhai, C Yang, J Wang, J Zhu, J Pan, W Jiang, Z Li, M Ye*, M Tan*, H Jiang*, Y Dang*. Integrative multi-omics and drug response characterization of patient-derived prostate cancer primary cells. Signal Transduct Target Ther. 2023, 8(175): 1-16.

    6. J Wang#, J Zhu#, J Hu#, Z Wang#, X Wang, J Pan, Y Chu, Z Li, W Jiang, C Liang*, J Hou*, J Guo*, Y Dang*, S Jiang*. A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells. Genes Dis. 2023, 10(6): 2586-2596.

    7. J Huang#, X Wang#, B Li#, S Shen, R Wang, H Tao, J Hu, J Yu, H Jiang, K Chen, C Luo*, Y Dang*, Y Zhang*. L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression. J Immunother Cancer. 2022, 6(10): e003957.

    8. S Fan#, L Yue#, W Wan#, Y Zhang#, B Zhang#, C Otomo, Q Li, T Lin, J Hu, P Xu, M Zhu, H Tao, Z Chen, L Li, H Ding, Z Yao, J Lu, Y Wen, N Zhang, M Tan, K Chen, Y Xie, T Otomo, B Zhou, H Jiang*, Y Dang*, C Luo*. Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein. Angew Chem Int Ed. 2021, 60(50): 26105-26114.

    9. N Sun, Q Xie, Y Dang*, Y Wang*. Agonist lock touched and untouched retinoic acid receptor-related orphan receptor-γt (RORγt) inverse agonists: classification based on the molecular mechanisms of action. J Med Chem. 2021, 64(15): 10519-10536.

    10. X Li#, Y Zhang#, Y Fu#, H Zhang, H Li, Q Li, H Li, R Tan, C Jiang, W Jiang, Z Li, C Luo*, B Lu*, Y Dang*. Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex. Acta Pharmacol Sin. 2021, 42(10): 1556-1566.

    11. Z Cui#, Y Liu#, W Wan#, Y Xu, Y Hu, M Ding, X Dou, R Wang, H Li, Y Meng, W Li, W Jiang, Z Li, Y Li, M Tan, DK Ma, Y Ding, JO Liu, C Luo*, B Yu*, Q Tang*, Y Dang*. Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. Protein Cell. 2021, 12(6): 493-501.

    12. R Tan, W Du, Y Liu, X Cong, M Bai, C Jiang, Z Li, M Tan, D Ma, Q Huang, W Jiang, Y Dang*. Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells. Genes Dis. 2020, 9(3): 731-740.

    13. Z Wang#, ZX Li#, WC Zhao, HB Huang, JQ Wang, H Zhang, JY Lu, RN Wang, W Li, Z Cheng, WL Xu, D Zhu, LS Zhou, W Jiang, L Yu, JY Liu, C Luo, H Zhu, D Ye, WJ Pan, JH Ju, YJ Dang*. Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B. Acta Pharmacol Sin. 2020, 42(5): 801-813.

    14. Z Sun#, H Zhang#, Y Zhang#, L Liao#, W Zhou#, F Zhang, F Lian, J Huang, P Xu, R Zhang, W Lu, M Zhu, H Tao, F Yang, H Ding, S Chen, L Yue, B Zhou, N Zhang, M Tan, H Jiang, K Chen, B Liu*, C Liu*, Y Dang*, C Luo*. Covalent inhibitors allosterically block the activation of Rho family proteins and suppress cancer cell invasion. Adv Sci. 2020, 7(14): 2000098.

    15. Z Li#, C Wang#, Z Wang#, C Zhu#, J Li, T Sha, L Ma, C Gao, Y Yang, Y Sun, J Wang, X Sun, C Lu, M Difiglia, Y Mei, C Ding, S Luo, Y Dang, Y Ding*, Y Fei*, B Lu*. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019, 575(7781): 203-209.

    16. C Jiang#, Y Tang#, L Ding#, R Tan, X Li, J Lu, J Jiang, Z Cui, Z Tang, W Li, Z Cao, TS Poetsch, W Jiang, C Luo, Y Ding*, J Liu*, Y Dang*. Targeting the N terminus of eIF4AI for inhibition of its catalytic recycling. Cell Chem Biol. 2019, 26(10): 1417-1426.

    17. S Jiang#, J Wang#, C Yang#, R Tan#, J Hou, Y Shi, H Zhang, S Ma, J Wang, M Zhang, G Philips, Z Li, J Ma, W Yu, G Wang, Y Wu, R Schlegel, H Wang, S Cao, J Guo*, X Liu*, Y Dang*. Continuous culture of urine-derived bladder cancer cells for precision medicine. Protein Cell. 2019, 10(12): 902-907.

    18. W Jiang#, X Zhou#, Z Li, K Liu, W Wang, R Tan, X Cong, J Shan, Y Zhan, Z Cui, L Jiang, Q Li, S Shen, M Bai, Y Cheng, B Li, M Tan, DK Ma, JO Liu, Y Dang*. Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of carabin. Blood. 2018, 131(12): 1325-1336.

    19. Z Li#, Z Cheng#, C Raghothama, Z Cui, K Liu, X Li, C Jiang, W Jiang, M Tan, X Ni, A Pandey, JO Liu, Y Dang*. USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1. Nucleic Acids Res. 2018, 46(2): 823-839.

    20. Y Yao#, S Sun#, F Fei, J Wang, Y Wang, R Zhang, J Wu, L Liu, X Liu, Z Cui, Q Li, M Yu, Y Dang*, X Wang*. Screening in larval zebrafish reveals tissue-specific distribution of fifteen fluorescent compounds. Dis Model Mech. 2017, 10(9): 1155-1164.

    21. P Lu, F Zhang, S Qian, X Li, Z Cui, Y Dang*, Q Tang*. Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function. Cell Res. 2016, 26(10): 1169-1172.

    22. J Lu#, C Jiang#, X Li#, L Jiang, Z Li, TS Poetsch, J Liu, K Yu, JO Liu, H Jiang, C Luo*, Y Dang*. A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation. Nucleic Acids Res. 2015, 43(21): 10157-10167.

    23. W Jiang, H Huang, L Ding, P Zhu, H Saiyin, G Ji, J Zuo, D Han, Y Pan, D Ding, X Ma, Y Zhang, J Wu, Q Yi, JO Liu, H Huang, Y Dang*, L Yu*. Regulation of cell cycle of hepatocellular carcinoma by NF90 through modulation of cyclin E1 mRNA stability. Oncogene. 2015, 34(34): 4460-4470.

    24. Y Dang#, TS Poetsch#, DE Eyler, JC Jewett, S Bhat, VH Rawal, R Green, JO Liu*. Inhibition of eukaryotic translation elongation by the antitumor natural product mycalamide B. RNA. 2011, 17(8): 1578-1588.

    25. Y Dang, WK Low, J Xu, NH Gehring, HC Dietz, D Romo, JO Liu*. Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J Biol Chem. 2009, 284(35): 23613-23621.

    26. Y Dang, N Kedersha, WK Low, D Romo, M Gorospe, R Kaufman, P Anderson, JO Liu*. Eukaryotic initiation factor 2α-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem. 2006, 281(43): 32870-32878.

    27. K Low#, Y Dang#, TS Poetsch, Z Shi, NS Choi, WC Merrick, D Romo, JO Liu*. Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Mol Cell. 2005, 20(5): 709-722.

      Featured in the review by Dr. Jon Clardy in ACS Chemical Biology "Stopping Trouble before It starts" 2005 Vol. 1 No. 1 p17; Highlighted in C & EN News "Protein Synthesis Nipped in the Bud" on December 19, 2005; Commented in "Faculty of 1000"

    28. H He#, Y Dang#, F Dai, Z Guo, J Wu, X She, Y Pei, Y Chen, W Ling, C Wu, S Zhao, JO Liu*, Y Long*. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem. 2003, 278(29278): 29287.

    相关附件: Natural product P57 induces hypothermia through targeting pyridoxal kinase.pdf Bis(benzonitrile) dichloroplatinum (II) interrupts PD-1:PD-L1 interaction by binding to PD-1.pdf Aurora A kinase inhibition elevates PD-L1 expression and compromises its anti-tumor efficacy.pdf Marine-derived natural product HDYL-GQQ-495 targets P62 to inhibit autophagy.pdf Integrative multi-omics and drug response characterization of patient-derived prostate cancer primary cells.pdf A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells.pdf L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression.pdf Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein.pdf Agonist Lock Touched and Untouched Retinoic Acid Receptor-Related Orphan RORγt Inverse Agonists.pdf Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP:p97-LC3-mHTT complex.pdf Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes.pdf Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells.pdf Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B.pdf Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.pdf Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds.pdf Targeting the N terminus of eIF4AI for inhibition of its catalytic recycling.pdf Continuous culture of urine-derived bladder cancer cells for precision medicine.pdf Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of carabin.pdf USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1.pdf Screening in larval zebrafish reveals tissue-specific distribution of fifteen fluorescent compounds.pdf Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function.pdf A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation.pdf Regulation of cell cycle of hepatocellular carcinoma by NF90 through modulation of cyclin E1 mRNA stability.pdf Inhibition of eukaryotic translation elongation by the antitumor natural product mycalamide B.pdf Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII.pdf Eukaryotic initiation factor 2α-independent pathway of stress granule induction by the natural product pateamine A.pdf Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.pdf Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.pdf