党永军，重庆市侨联委员，国家级人才计划特聘教授，重庆医科大学特聘教授、药学院院长、新靶标与化学干预教育部医药基础研究创新中心主任，博士生导师。重庆英才·创新创业领军人才，巴渝学者计划讲座教授，重庆市教委高水平科研创新平台培育工程研究中心负责人，重庆市高校创新研究群体负责人，上海市人才发展基金获得者。复旦大学遗传所博士，美国约翰霍普金斯大学医学院博士后。中国药理学会海洋药物药理专业委员会副主任委员，全国卫生产业企业管理协会医学遗传专委会常务委员，上海药理学会常务理事，中国药学会第一届智能药物专业委员会委员，国家自然基金委二审专家。

主要从事与疾病相关新靶标和小分子化合物的发现、确证以及转化医学研究。系统地建立了与疾病相关的分子靶标鉴定和小分子筛选体系，取得了系列原创性成果。近五年在重大疾病新靶标发现领域，以通讯作者身份在Signal Transduct Target Ther、Blood、J Clin Investig、Nucleic Acids Res、Nat Commun、Angew Chem Int Ed、Adv Sci等知名期刊发表论文18篇，其中影响因子大于10分的论文8篇。文章他引超6,500次，H指数36。主持国家自然科学基金重点项目1项，面上项目3项，参与国家重点研发计划“深海关键技术与装备”重点专项子课题1项。申请专利31项，实现项目转化7项，转化总金额3.28亿人民币。担任Blood、Cell Chem Biol、Bioorg Med Chem Lett、Exp Cell Res、ACS Synth Biol等知名杂志审稿人。

主要研究方向：1）天然产物和药物的分子靶点鉴定和作用机制研究；2）基于小分子探针的基础生物学理论研究；3）建立适于高通量筛选的细胞和动物模型用于新药的筛选和研发。

代表性论文：

1. R Wang^#, L Xiao^#, J Pan^#, G Bao^#, Y Zhu, D Zhu, J Wang, C Pei, Q Ma, X Fu, Z Wang, M Zhu, G Wang, L Gong, Q Tong, M Jiang, J Hu, M He, Y Wang, T Li, C Liang, W Li, C Xia, Z Li, DK Ma, M Tan, JY Liu, W Jiang^*, C Luo^*, B Yu^*, Y Dang^*. Natural product P57 induces hypothermia through targeting pyridoxal kinase. Nat Commun. 2023, 14(5984): 1-15.

2. RN Wang^#, Q Yu^#, XB Wang, D Zhu, GL Li, ZX Li, W Jiang^*, W Li^*, YJ Dang^*. Bis(benzonitrile) dichloroplatinum (II) interrupts PD-1/PD-L1 interaction by binding to PD-1. Acta Pharmacol Sin. 2023, 44: 2103-2112.

3. X Wang^#, J Huang^#, F Liu^#, Q Yu, R Wang, J Wang, Z Zhu, J Yu, J Hou, JS Shim, W Jiang^*, Z Li^*, Y Zhang^*, Y Dang^*. Aurora A kinase inhibition elevates PD-L1 expression and compromises its anti-tumor efficacy. J Clin Investig. 2023, 133(9): e161929.

4. Q Li^#, J Fan^#, Y Chen, Y Liu, H Liu, W Jiang^*, D Li^*, Y Dang^*. Marine-derived natural product HDYL-GQQ-495 targets P62 to inhibit autophagy. Mar Drugs. 2023, 21 (2): 68.

5. Z Wang^#, Y Li^#, W Zhao^#, S Jiang^#, Y Huang, J Hou, X Zhang, Z Zhai, C Yang, J Wang, J Zhu, J Pan, W Jiang, Z Li, M Ye^*, M Tan^*, H Jiang^*, Y Dang^*. Integrative multi-omics and drug response characterization of patient-derived prostate cancer primary cells. Signal Transduct Target Ther. 2023, 8(175): 1-16.

6. J Wang^#, J Zhu^#, J Hu^#, Z Wang^#, X Wang, J Pan, Y Chu, Z Li, W Jiang, C Liang^*, J Hou^*, J Guo^*, Y Dang^*, S Jiang^*. A novel in vitro prognostic model of bladder cancer based on urine-derived living tumor cells. Genes Dis. 2023, 10(6): 2586-2596.

7. J Huang^#, X Wang^#, B Li^#, S Shen, R Wang, H Tao, J Hu, J Yu, H Jiang, K Chen, C Luo^*, Y Dang^*, Y Zhang^*. L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression. J Immunother Cancer. 2022, 6(10): e003957.

8. S Fan^#, L Yue^#, W Wan^#, Y Zhang^#, B Zhang^#, C Otomo, Q Li, T Lin, J Hu, P Xu, M Zhu, H Tao, Z Chen, L Li, H Ding, Z Yao, J Lu, Y Wen, N Zhang, M Tan, K Chen, Y Xie, T Otomo, B Zhou, H Jiang^*, Y Dang^*, C Luo^*. Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein. Angew Chem Int Ed. 2021, 60(50): 26105-26114.

9. N Sun, Q Xie, Y Dang^*, Y Wang^*. Agonist lock touched and untouched retinoic acid receptor-related orphan receptor-γt (RORγt) inverse agonists: classification based on the molecular mechanisms of action. J Med Chem. 2021, 64(15): 10519-10536.

10. X Li^#, Y Zhang^#, Y Fu^#, H Zhang, H Li, Q Li, H Li, R Tan, C Jiang, W Jiang, Z Li, C Luo^*, B Lu^*, Y Dang^*. Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex. Acta Pharmacol Sin. 2021, 42(10): 1556-1566.

11. Z Cui^#, Y Liu^#, W Wan^#, Y Xu, Y Hu, M Ding, X Dou, R Wang, H Li, Y Meng, W Li, W Jiang, Z Li, Y Li, M Tan, DK Ma, Y Ding, JO Liu, C Luo^*, B Yu^*, Q Tang^*, Y Dang^*. Ethacrynic acid targets GSTM1 to ameliorate obesity by promoting browning of white adipocytes. Protein Cell. 2021, 12(6): 493-501.

12. R Tan, W Du, Y Liu, X Cong, M Bai, C Jiang, Z Li, M Tan, D Ma, Q Huang, W Jiang, Y Dang^*. Nucleolus localization of SpyCas9 affects its stability and interferes with host protein translation in mammalian cells. Genes Dis. 2020, 9(3): 731-740.

13. Z Wang^#, ZX Li^#, WC Zhao, HB Huang, JQ Wang, H Zhang, JY Lu, RN Wang, W Li, Z Cheng, WL Xu, D Zhu, LS Zhou, W Jiang, L Yu, JY Liu, C Luo, H Zhu, D Ye, WJ Pan, JH Ju, YJ Dang^*. Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B. Acta Pharmacol Sin. 2020, 42(5): 801-813.

14. Z Sun^#, H Zhang^#, Y Zhang^#, L Liao^#, W Zhou^#, F Zhang, F Lian, J Huang, P Xu, R Zhang, W Lu, M Zhu, H Tao, F Yang, H Ding, S Chen, L Yue, B Zhou, N Zhang, M Tan, H Jiang, K Chen, B Liu^*, C Liu^*, Y Dang^*, C Luo^*. Covalent inhibitors allosterically block the activation of Rho family proteins and suppress cancer cell invasion. Adv Sci. 2020, 7(14): 2000098.

15. Z Li^#, C Wang^#, Z Wang^#, C Zhu^#, J Li, T Sha, L Ma, C Gao, Y Yang, Y Sun, J Wang, X Sun, C Lu, M Difiglia, Y Mei, C Ding, S Luo, Y Dang, Y Ding^*, Y Fei^*, B Lu^*. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019, 575(7781): 203-209.

16. C Jiang^#, Y Tang^#, L Ding^#, R Tan, X Li, J Lu, J Jiang, Z Cui, Z Tang, W Li, Z Cao, TS Poetsch, W Jiang, C Luo, Y Ding^*, J Liu^*, Y Dang^*. Targeting the N terminus of eIF4AI for inhibition of its catalytic recycling. Cell Chem Biol. 2019, 26(10): 1417-1426.

17. S Jiang^#, J Wang^#, C Yang^#, R Tan^#, J Hou, Y Shi, H Zhang, S Ma, J Wang, M Zhang, G Philips, Z Li, J Ma, W Yu, G Wang, Y Wu, R Schlegel, H Wang, S Cao, J Guo^*, X Liu^*, Y Dang^*. Continuous culture of urine-derived bladder cancer cells for precision medicine. Protein Cell. 2019, 10(12): 902-907.

18. W Jiang^#, X Zhou^#, Z Li, K Liu, W Wang, R Tan, X Cong, J Shan, Y Zhan, Z Cui, L Jiang, Q Li, S Shen, M Bai, Y Cheng, B Li, M Tan, DK Ma, JO Liu, Y Dang^*. Prolyl 4-hydroxylase 2 promotes B-cell lymphoma progression via hydroxylation of carabin. Blood. 2018, 131(12): 1325-1336.

19. Z Li^#, Z Cheng^#, C Raghothama, Z Cui, K Liu, X Li, C Jiang, W Jiang, M Tan, X Ni, A Pandey, JO Liu, Y Dang^*. USP9X controls translation efficiency via deubiquitination of eukaryotic translation initiation factor 4A1. Nucleic Acids Res. 2018, 46(2): 823-839.

20. Y Yao^#, S Sun^#, F Fei, J Wang, Y Wang, R Zhang, J Wu, L Liu, X Liu, Z Cui, Q Li, M Yu, Y Dang^*, X Wang^*. Screening in larval zebrafish reveals tissue-specific distribution of fifteen fluorescent compounds. Dis Model Mech. 2017, 10(9): 1155-1164.

21. P Lu, F Zhang, S Qian, X Li, Z Cui, Y Dang^*, Q Tang^*. Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function. Cell Res. 2016, 26(10): 1169-1172.

22. J Lu^#, C Jiang^#, X Li^#, L Jiang, Z Li, TS Poetsch, J Liu, K Yu, JO Liu, H Jiang, C Luo^*, Y Dang^*. A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation. Nucleic Acids Res. 2015, 43(21): 10157-10167.

23. W Jiang, H Huang, L Ding, P Zhu, H Saiyin, G Ji, J Zuo, D Han, Y Pan, D Ding, X Ma, Y Zhang, J Wu, Q Yi, JO Liu, H Huang, Y Dang^*, L Yu^*. Regulation of cell cycle of hepatocellular carcinoma by NF90 through modulation of cyclin E1 mRNA stability. Oncogene. 2015, 34(34): 4460-4470.

24. Y Dang^#, TS Poetsch^#, DE Eyler, JC Jewett, S Bhat, VH Rawal, R Green, JO Liu^*. Inhibition of eukaryotic translation elongation by the antitumor natural product mycalamide B. RNA. 2011, 17(8): 1578-1588.

25. Y Dang, WK Low, J Xu, NH Gehring, HC Dietz, D Romo, JO Liu^*. Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII. J Biol Chem. 2009, 284(35): 23613-23621.

26. Y Dang, N Kedersha, WK Low, D Romo, M Gorospe, R Kaufman, P Anderson, JO Liu^*. Eukaryotic initiation factor 2α-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem. 2006, 281(43): 32870-32878.

27. K Low^#, Y Dang^#, TS Poetsch, Z Shi, NS Choi, WC Merrick, D Romo, JO Liu^*. Inhibition of eukaryotic translation initiation by the marine natural product pateamine A. Mol Cell. 2005, 20(5): 709-722.

    Featured in the review by Dr. Jon Clardy in ACS Chemical Biology "Stopping Trouble before It starts" 2005 Vol. 1 No. 1 p17; Highlighted in C & EN News "Protein Synthesis Nipped in the Bud" on December 19, 2005; Commented in "Faculty of 1000"

28. H He^#, Y Dang^#, F Dai, Z Guo, J Wu, X She, Y Pei, Y Chen, W Ling, C Wu, S Zhao, JO Liu^*, Y Long^*. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem. 2003, 278(29278): 29287.