谌錾，特聘教授，博士生导师。2012年获北京大学医学学士学位，2017年获美国约翰霍普金斯大学药理学博士学位，2017-2020年在哈佛医学院细胞生物学系Wade Harper教授课题组进行博士后研究，2021年在约翰霍普金斯大学Bert Vogelstein和Sandra Gabelli教授课题组完成博士后研究后加入重庆医科大学生命科学研究院新靶标与化学干预研究中心。
主要研究方向为蛋白质翻译后修饰：结合蛋白组学和基因编辑技术，探究蛋白质翻译后修饰尤其是磷酸化和泛素化修饰在疾病发生发展中的动态调控和功能，寻找具有靶标意义的修饰位点和相关酶类；利用蛋白质半合成技术和结构生物学，研究翻译后修饰调控的生化特性和分子细节；结合新靶标与化学干预研究中心的平台优势，开发针对翻译后修饰相关重要靶点的小分子药物。
联系方式：zanchen@cqmu.edu.cn
代表性论文：
Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes PN, Wolberger C, Amzel M, Gabelli S*, Cole PA*. “A tunable brake for HECT ubiquitin ligases.” Molecular Cell. 2017, 66 (3): 345-375. (Featured article, highlighted by Cancer Discovery)
Chen Z#, Dempsey DR#, Thomas SN, Heyward D, Bolduc DM, Cole PA*. “Molecular features of phosphatase and tensin homolog (PTEN) C-terminal phosphorylation.” Journal of Biological Chemistry. 2016, 291 (27): 16160-16169. (Featured article)
Chen Z, Thomas SN, Bolduc DM, Zhang X, Wolberger C, Jiang X, Cole PA*. “Enzymatic analysis of PTEN ubiquitination by WWP2 and NEDD4-1 E3 ligases.” Biochemistry. 2016, 55 (26): 3658-3666.
Chen Z, Cole PA*. “Synthetic approaches to protein phosphorylation.” Current Opinion in Chemical Biology. 2015, 28: 115-122.
Chen Z, Huang C, Yang Y, Ding Y, Zhang Y, Xu M*. “Inhibition of STAT3 signaling pathway is involved in the antitumor activity of Cepharanthine in SaOS2 cells.” Acta Pharmacologica Sinica. 2012, 33 (1): 101-108.
Dempsey DR#, Viennet T#, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA*. “The structural basis of PTEN regulation by multi-site phosphorylation.” Nat Struct Mol Biol. 2021, 28(10):858-868.
Jiang H, Thomas SN, Chen Z, Chiang CY, Cole PA*. “Comparative analysis of the catalytic regulation of NEDD4-1 and WWP2 ubiquitin ligases.” Journal of Biological Chemistry. 2019, 294 (46): 17421-17436.
Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB*, Cole PA*. “Akt kinase activation mechanisms revealed using protein symisynthesis.” Cell. 2018, 174 (4): 897-907.
Dempsey DR, Jiang H, Kalin JH, Chen Z, Cole PA*. “Site-specific protein labeling with N-Hydroxysuccinimide-esters and the analysis of ubiquitin ligase mechanisms.” Journal of American Chemical Society. 2018, 140 (30): 9374-9378.
Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, Jimenez R, Xiao J, Dedecker P, Zhang J*. "Genetically-encoded biosensors for visualizing live-cell biochemical activity at super-resolution." Nature Methods. 2017, 14 (4): 427-434.
Henager SH#, Chu N#, Chen Z, Bolduc DM, Dempsey DR, Hwang Y, Wells J, Cole PA*. “Enzyme catalyzed expressed protein ligation.” Nature Methods. 2016, 13 (11): 925-927.
Taylor MS, Dempsey DR, Hwang Y, Chen Z, Chu N, Boeke JD, Cole PA*. “Mechanistic analysis of ghrelin-O-acyltransferase using substrate analogs.” Bioorganic Chemistry. 2015, 62: 64-73.
Wang Y, Kavran JJ, Chen Z, Karukurichi KR, Leahy DJ, Cole PA*. “Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.” Journal of Biological Chemistry. 2014, 289 (45): 31361-31372.
Fang Z, Li Y, Chen Z, Chen J, Zhu L*. “Inhibition of signal transducer and activator of transcription 3 and cyclooxygenase-2 is involved in radiosensitization of cepharanthine in HeLa cells.” International Journal of Gynecological Cancer. 2013, 23 (4): 608-614.
Lin S#, Li S#, Chen Z, He X, Xu X, Zhang Y, Xu M*, Yuan Gu*. “Formation, recognition and bioactivities of a novel G-quadruplex in the STAT3 gene.” Bioorganic & Medicinal Chemistry Letters. 2011, 21 (19): 5987-5991.
