袁海心，教授，博士生导师。2002年毕业于中国科学技术大学，获理学学士学位；2009年毕业于中国科学院上海生化细胞研究所，获生物化学与分子生物学博士学位；2009-2014年在美国加州大学圣迭戈分校做博士后，从事细胞生长与细胞自噬的调控机制研究。2014年11月受聘于复旦大学生物医学研究院，任青年研究员/PI；2019年12月晋升为研究员/PI。2021年10月加入重庆医科大学生命科学研究院新靶标与化学干预研究中心。

袁海心教授关注细胞代谢与死亡调控机制的研究，已发表学术论文30余篇（总影响因子逾500），近年在Nature Commun、Cancer Res、Oncogene等知名期刊发表通讯作者论文多篇。获得国家自然科学基金面上项目（4项）、国家科技重大专项和国家重点研发计划等资金支持，并入选上海高校特聘教授（东方学者）和上海市人才发展资金等人才计划、重庆市留学人员回国创业创新支持计划（重点项目）以及重庆医科大学重大科技人才项目“揭榜挂帅”计划（A类）等重要人才计划支持。

研究方向：细胞代谢与死亡调控机制

（1）代谢紊乱是肿瘤及多种疾病发生的重要原因，本课题组致力于细胞生长与代谢机制的研究，运用生物化学、细胞生物学以及动物模型等实验手段，研究与肿瘤等疾病相关的信号转导通路、代谢酶的翻译后修饰（磷酸化、乙酰化和泛素化等）以及代谢酶突变等重要问题，期望揭示代谢异常与人类重大疾病尤其是肿瘤的关系。

（2）铁死亡是近年来发现的一种新型细胞死亡方式，它由细胞内脂质过氧化物累积而导致，与细胞内的脂质代谢平衡密切相关；然而关于铁死亡的调控机制和生理功能仍有许多未知。本课题组利用高通量筛选的方法寻找并阐明铁死亡调控的关键基因和信号通路，并利用动物模型研究铁死亡与糖脂代谢异常相关疾病的关系，为疾病治疗提供新的策略。

联系方式：yuanhaixin@cqmu.edu.cn

代表性论文：

1. Liu JP^#, Cen SY^#, Xue Z, Wang TX, Gao Y, Zheng J, Zhang C, Hu J, Nie S, Xiong Y, Guan KL, Yuan HX*. A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. ACS Chem Biol. 2022, 17(12):3389-3406.

2. Sun SJ^#, Ai Y^#, Duan KL, Zhang JY, Zhang C, Sun YP, Xiong Y, Guan KL, and Yuan HX*. TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression. Oncogene 2022,41（50）：5385-5396.

3. Wang TX^#, Duan KL^#, Huang ZX, Xue ZA, Liang JY, Dang Y, Zhang A, Xiong Y, Ding C*, Guan KL and Yuan HX*. Tanshinone functions as a coenzyme that confers gain-of-function of NQO1 to suppress ferroptosis. Life Sci Alliance 2022, 6（1）：e202201667.

4. Hu M^#, Bao R^#, Lin M^#, Han XR, Ai YJ, Gao Y, Guan KL, Xiong Y, and Yuan HX*. ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3. Oncogene 2022, 41（40）:4547-4559.

5. Liu P^#, Sun SJ^#, Ai Y^#, Feng X, Zheng YM, Gao Y, Zhang JY, Zhang L, Sun YP, Xiong Y, Lin M*, and Yuan HX*.Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance. Cell Death Dis. 2022, 13（3）:205.

6. Bao R, Meng Y, Zhang H, Yang C, Li W, Zhang C, Zhang J, Sun R, Li Z, Jiang W, Zhang C, Zhang C*, Yuan HX*, and Dang Y*. Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK. Cell Death Dis. 2021 ，12（11）：972.

7. Liu P^#, Liu JP^#, Sun SJ^#, Gao Y, Ai Y, Chen X, Sun Y, Zhou M, Liu Y, Xiong Y, and Yuan HX. CBFB-MYH11 fusion sequesters RUNX1 in cytoplasm to prevent DNMT3A recruitment to target genes in AML. Front Cell Dev Biol. 2021, 9:675424.

8. Li X, Wang TX, Huang X, Li Y, Sun T, Zang S, Guan KL, Xiong Y, Liu J*, Yuan HX*. Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity. Liver Int. 2020, 40（6）:1378-1394.

9. Wang TX, Liang JY, Zhang C, Xiong Y, Guan KL and Yuan HX. The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis. Cell Death Dis. 2019, 10（10）:755.

10. Li MT, Liang JY, Sun YP, Jin J, Xiong Y, Guan KL, and Yuan HX. ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK). Biochem J. 2019, 476（15）:2239-2254.

11. Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL and Yuan HX. Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis. Nat Commun. 2018, 9（1）:508.

12. Liu MX, Jin L, Sun SJ, Liu P, Feng X, Cheng ZL, Liu WR, Guan KL, Shi YH*, Yuan HX* and Xiong Y*. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma. Oncogene 2018, 37（12）:1637-1653.

13. Mo Y, Lin R, Liu P, Tan M, Xiong Y, Guan KL, Yuan HX. SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. FEBS J. 2017, 284（21）: 3619-3636.

14. Wang Z, Liu P, Zhou X, Wang T, Feng X, Sun YP, Xiong Y*, Yuan HX*, and Guan KL*. Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ. Cancer Res. 2017, 77（9）: 2413-2423.

15. Feng X, Liu P, Zhou X, Li MT, Li FL, Wang Z, Meng ZP, Sun YP, Yu Y, Xiong Y*, Yuan HX*, and Guan KL*. Thromboxane A2 Activates YAP/TAZ to Induce Vascular Smooth Muscle Cell Proliferation and Migration. J Biol Chem. 2016, 291（36）: 18947-18958.

16. Yuan HX* and Guan KL*. Structural insights of mTOR complex 1. Cell Res. 2016, 26（3）: 267-268.

17. Yuan HX, Wang Z, Yu FX, Li F, Russell RC, Jewell JL, and Guan KL. NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition. Gene Dev. 2015, 29（22）: 2362-2376.

18. Yuan HX and Guan KL. The SIN1-PH Domain Connects mTORC2 to PI3K. Cancer Discov. 2015, 5（11）: 1127-1129.

19. Yuan HX, Russell RC, and Guan KL. Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy. Autophagy 2013, 9（12）: 1983-1995.

20. Yuan HX, Xiong Y, and Guan KL. Nutrient sensing, metabolism, and cell growth control. Mol Cell. 2013, 49（3）: 379-387.

21. Yuan H^#, Zhang H^#, Wu X, Zhang Z, Du D, Zhou W, Zhou S, Brakebusch C, and Chen Z. Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice. Hepatology 2009, 49（1）: 240-249.

22. Yuan H^#, Zhang L, Liu A, Zhou H, Wang Y, Zhang H, Wang G, Zeng R, Zhang Y, and Chen Z. Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions. J Proteome Res. 2006, 5（2）: 299-307.